By Professor Dr. Alvaro Macieira-Coelho (auth.)
This quantity provides the reader a accomplished assessment of the basic and organic elements of getting older. First, the sphere is defined from a historic point of view. Then, the writer analyzes the 3 primary mechanisms of survival: power usage, molecular and mobile redundancy, and the association of data. The genetics of getting older is reviewed rejecting a few simple-minded interpretations. A bridge is demonstrated among the molecular, mobile, and tissue changes which were mentioned within the literature, and the medical manifestations of the getting older syndrome. unique relevance is given to the matter of the meant organization among cancers and getting older, giving a brand new interpretation of that relationship.
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It also led to increased intelligence, and thus to the possibility of avoiding environmental hazards. The neocortex volume has also a bearing with aging, as we will describe later, through its influence on the slow embryonic development of humans. Sacher's evolutionary interpretation seems more realistic than any of the other theories mentioned above. The human species is also the only one where, thanks to the brain, aging improves the chances of survival of the offspring. While in other species aging decreases the capacity for survival in the environmental niche, in humans the knowledge and experience that accumulate during a lifetime and are processed by the brain can be used by the individual for its own survival and transmitted to the descendents to the benefit of increasing longevity.
Hematopoietic tissue and skin; and terminal differentiated cells with a null or slower renewal capacity such as neurons and striated muscle. Senescence occurs through different mechanisms in each compartment. The cell division potential of fibroblasts described in Weismann's theory constitutes an example of information stored in cells that distinguishes species and which is related to survival and to patterns of development and senescence. Why should fibroblasts manifest this relationship? This has to be seen in the face of the role of the mesenchyme during development and in homeostasis.
There are also regulations taking place downstream of gene expression through the different steps of the synthesis of functional molecules, at the level of the interaction of proteins, and down to their elimination. Furthermore, the genome cannot be the sole determinant of the life span in such complex systems as mammalian organisms. As pointed out by Sacher (1975), life span is the expression of the total capability of a set of physiological, biochemical, and behavioral performances directed towards stabilizing the organism and maintaining life.