By Peter B. Gahan (auth.), Peter B. Gahan (eds.)
DNA and RNA fractions were remoted from various resources together with: complete blood, serum, plasma, the skin of blood cells, urine, saliva and spinal fluid from either fit members and sufferers. the facility to isolate, quantify, and research those molecules has ended in the identity of particular nucleic acid fragments on the topic of a number of scientific problems thereby allowing their early analysis and analysis. This quantity encompasses the complaints of the sixth foreign convention on circulating nucleic acids in plasma and serum held from the ninth to the eleventh of November 2009 in Hong Kong. the subjects which are lined in those court cases comprise: - Nucleic Acids in Oncology - Nucleic Acids in Foetal medication - The Biology of CNAPS - New applied sciences for CNAPS - different scientific Exploitation of CNAPS
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Extra resources for Circulating Nucleic Acids in Plasma and Serum: Proceedings of the 6th international conference on circulating nucleic acids in plasma and serum held on 9-11 November 2009 in Hong Kong.
This was followed by a test for leukemia exploiting the circulating DNA that was published in the British Journal of Haematology (Vasioukhin et al. 1994), five scientific journals having previously rejected our paper! Many laboratories successfully followed in ours steps looking for tests for different cancers (see Anker and Stroun 2001). At the first International Symposium on Circulating DNA in Annecy in 1999, the big event was the work of Professor Dennis Lo showing that it was possible to bypass the amniosyntesis for a pregnant woman in order to detect some foetal abnormalities using CNAPS.
In addition, analysis of circulating DNA is a minimally invasive and cost effective assay, and allows serial assessments to follow disease progression and monitor therapy. Different approaches have been used to study circulating DNA in PCa. Absolute DNA levels, DNA fragmentation, mitochondrial DNA, allelic imbalance (AI), and promoter hypermethylation have all shown promising diagnostic and/or prognostic values, as recently reviewed (Ellinger et al. 2009). Among these, genetic and epigenetic alterations are of valuable interest because they can not only detect PCa, but also provide clues about the biology of the tumor.
References Lander ES, Linton LM, Birren B et al (2001) Initial sequencing and analysis of the human genome. Nature 409:860–921 Meyer M, Stenzel U, Myles S et al (2007) Targeted high-throughput sequencing of tagged nucleic acid samples. Nucleic Acids Res 35:e97 Scherer S (2008) A short guide to the human genome, 1st edn. Cold Spring Harbor Laboratory Press, New York, NY van der Vaart M, Pretorius PJ (2010) Is the role of circulating DNA as a biomarker of cancer being prematurely overrated? Clin Biochem 43:26–36 van der Vaart M, Semenov DV, Kuligina EV et al (2009) Characterization of circulating DNA by parallel tagged sequencing on the 454 platform.