Download Control of Messenger RNA Stability by Joel G. Belasco, George Brawerman PDF

By Joel G. Belasco, George Brawerman

This is often the 1st accomplished assessment of mRNA balance and its implications for law of gene expression. Written by way of specialists within the box, Control of Messenger RNA Stability serves either as a reference for experts in law of mRNA balance and as a basic advent for a broader neighborhood of scientists.

  • Provides views from either prokaryotic and eukaryotic systems
  • Offers a well timed, entire evaluation of mRNA degradation, its legislation, and its importance within the keep watch over of gene expression
  • Discusses the mechanisms, RNA structural determinants, and mobile components that keep watch over mRNA degradation
  • Evaluates experimental approaches for learning mRNA degradation

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Extra info for Control of Messenger RNA Stability

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C , Simons, E. L . , and Simons, R. W. (1990). The IS20 transposase mRNA is destabi­ lized during antisense control. EMBO J. 9, 1259-1266. Chen, C-Y. , Beatty, J. , Cohen, S. , and Belasco, J. G. (1988). An intercistronic stem-loop structure functions as an mRNA decay terminator necessary but insufficient for puf mRNA stability. Cell 52, 6 0 9 - 6 1 9 . Chen, C-Y. , and Belasco, J. G. (1990). Degradation of pufLMX mRNA in Rhodobacter capsulatus is initiated by nonrandom endonucleolytic cleavage.

Donovan, W. , and Kushner, S. R. (1986). Polynucleotide phosphorylase and ribonuclease II are required for cell viability and mRNA turnover in Escherichia coli K-12. Proc. Natl. Acad. Sci. USA 83, 120-124. Ehretsmann, C. , Carpousis, A. J . , and Krisch, H. M. (1992). Specificity of E. coli endoribonuclease RNase E: In vivo and in vitro analysis of mutants in a bacteriophage T4 mRNA processing site. Genes Dev. 6, 149-159. Emory, S. , and Belasco, J. G. (1990). The ompA 5' untranslated RNA segment functions in Escherichia coli as a growth-rate-regulated mRNA stabilizer whose activity is unrelated to translational efficiency.

5 1 7 - 5 5 3 . Academic Press, New York. Mackie, G. A. (1987). Posttranscriptional regulation of ribosomal protein S20 and stability of the S20 mRNA species. /. Bacteriol. 169, 2697-2701. 2. The Role of the 3' End in mRNA Stability and Decay 29 Mackie, G. A. (1989). Stabilization of the 3' one-third of Escherichia coli ribosomal protein S20 mRNA in mutants lacking polynucleotide phosphorylase. /. Bacteriol. 171, 4112-4120. McLaren, R. , Newbury, S. , Dance, G. S. , Causton, H. , and Higgins, C.

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